Direct bonding to the sulfhydryl group of GSH in the cytoplasm has been shown to inactivate cisplatin, for example
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coli CARS for this reaction to be 7.4 M, which is sufficiently low relative to intracellular cysteine concentrations (1001000 M) ( E
In a small open-label trial of exenatide in people with clozapine-associated obesity (BMI 3045 kg/m 2 ), those on exenatide had about 10 pounds more weight loss than placebo at 24 weeks (Siskind D et al, J Psychiatr Res 2020;124:912)
When NAD+ levels drop, ATP production becomes less efficient
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