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Chronic uninterrupted use beyond 4 weeks lacks safety data

Weeks three through four show gradual improvement as metabolic adaptation occurs

The C-terminal domain contributes, together with the N-terminal domain, to shaping the co-substrate binding site, which is termed H-site, from the hydrophobic nature of co-substrates

Provided thyroid function is stable and TSH levels are within the target range, there is no pharmacological reason why Mounjaro cannot be initiated

But it wont replace moisturizer

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