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Loading phase: Initial protocols often use 2-2.5mg twice weekly for 4-6 weeks
Severe allergic reactions are very rare and almost exclusively associated with injectable rather than oral B12
Sikiric's Research Legacy Dr
Vitamin D is crucial for fertility
B12 injections (hydroxocobalamin) are licensed medicines available on NHS prescription for treating confirmed B12 deficiency
Alternative targets in TED include IL-17a (blocked by the IgG1s secukinumab (Cosentyx) and vunakizumab (NCT04737330, NCT05394857)), the IL-11 receptor (NCT05331300), the IL-6 receptor (NCT05331300), and vascular endothelial growth factor (NCT04311606)
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