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1) invitro
The "Bottom Line" column reveals the storage dilemma: lyophilised powder offers maximum stability but requires reconstitution skill
Lets see how: In the foetus: heart disease, and intrauterine growth restriction Newborns: poor feeding, microcephaly (smaller than usual head size), and encephalopathy Infants: poor feeding, slow growth, and neurologic complications Toddlers: poor growth, progression of microcephaly, encephalopathy, megaloblastic anemia, developmental delays, and seizures Adolescents and adults: neurologic and psychiatric illness, cognitive decline, abnormal clot formation, spinal cord degeneration
(2000) Evaluation of low-dose endotoxin administration during pregnancy as a model of preeclampsia
Minimises handling and preparation requirements
Rotate injection sites systematically to prevent tissue irritation and lipodystrophy with repeated use
