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Lower baseline VAT metabolism levels were associated with greater weight reduction by GLP-1 medications, thus indicating that people with low VAT metabolic activities might benefit the most from the dual effects of GLP-1 treatment on reduced calorie intake and enhanced metabolic activity
(EASY Pharmacology) How do GLP-1 Agonists work
However, rapid weight loss combined with muscle loss may temporarily destabilize the spine until strength is rebuilt
In clinical use, significant side effects are uncommon, and the vast majority of patients tolerate the therapy without problems
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