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Category 2 These substances raised significant FDA safety concerns

Additionally, keratinocytes and Langerhans cells (LCs), release cytokines such as IL-10, IL-12, IL-18, IL-23, IL-17 and IL-22 and thymic stromal lymphopoietin (TSLP), leading to an enhanced Th2-type inflammatory response (48, 50, 51)

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Research outcomes can vary by study design, conditions, and model used

Inflammatory markers, ROS, and matrix metalloproteinases (MMPs), as the factors to enhance BBB permeability, can be released by the infiltrated activated leukocytes in MS cases (Larochelle et al., 2011)

This triggers the cAMP signalling cascade, which activates protein kinase A (PKA), leading to hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) activation, resulting in triglyceride hydrolysis in adipocyte cell models