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Research published eLife (PMID: 36345724) sought to answer the questions Do differences in metabolites in the brain affect our capacity for motivation?, If that is the case, could nutritional interventions that affect metabolite levels be an effective vehicle to improve motivated performance? The researchers measured levels of the antioxidant glutathione in the nucleus accumbens of humans and rats and compared these levels to performance in effort-related tasks that assessed motivation
The expression level of HIF-1, VEGF, and glucose transporter protein 1 was found to be increased significantly using the immunohistochemical technique in 58 patients with pancreatic cancer and 20 normal human tissue samples
Glutathione also helps repair damaged tissues, such as in the case of leaky gut
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However levels may decrease due to illness, age, bad diet or exposure to sun too often
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