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Cocaine is a highly addictive stimulant that restricts dopamine and monoamine reuptake through dopamine transporter (DAT) antagonism ( An alternate pathway for cocaine-induced BBB permeability alteration involves platelet-derived growth factor (PDGF) intermediates (Yao et al., 2011)

Signs of copper excess include nausea, vomiting, abdominal pain, and in severe cases, liver damage

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Starting both agents at lower doses than typically used for monotherapy and escalating more slowly can improve tolerability

Next up well tackle side effects which is in my opinion one of the rate limiters for my personal excitement for this drug class