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Signals are compelling enough to demand conversation and monitoring, even if definitive rules are not established
The standard dosage range of 50-150 mg daily for oral administration aligns with calculated human equivalent doses from animal research
It should not be used in neonates, pregnant women, certain medications, or for intrathecal injection
However, the largest 24-week trial with 536 participants failed to show statistically significant weight loss, which led to development termination
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