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Glutathione, often called the master antioxidant , is a powerful antioxidant that exists naturally in the body, protecting cells from damage and supporting immune function

As a soft nucleophile it conjugates electrophiles in glutathione S-transferase-catalysed phase-II reactions

Glutathione for athletes strengthens the immune system by reducing oxidative stress and protecting against harmful pathogens

Sumida K, Molnar MZ, Potukuchi PK, et al

6 , eaaz1580 (2020)

Thus, roGFP2 oxidation does not efficiently occur via a Grx(SSR) intermediate and we can exclude the dithiol mechanism and monothiol mechanism (i) for roGFP2 oxidation (reverse reactions in Fig