active glp 1 G protein-coupled receptors driven intestinal glucagon-like peptide-1 reprogramming for obesity: Hope or hype? GLP-1 tablets are here. Curious

While long-term data is still needed, the immediate safety picture is much more encouraging than previously thought

This does not invalidate the findings, but it is a standard scientific quality consideration that most pages omit

Nearly one-third of patients discontinued treatment during the study period, most often due to gastrointestinal side effects or insurance coverage issues

The medication's weight loss effects are primarily driven by appetite suppression through central nervous system effects, with the gastric emptying delay contributing to early satiety

doi: 10.1038/s41590-023-01661-4 71 GriffinDE

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