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In animal models, goat milk yogurt supplemented with red rice bran flour was tested, and goat milk fermentation generated bioactive peptides with antioxidant, antibacterial, and antihypertensive properties

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The histidine residue provides the primary copper-binding site

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Structural optimization revealed that incorporating small hydrophobic groups, such as cyclopropylmethyl, at the N 7 -position enhanced potency, while a sulfonyl group at the N 2 -position and (4-fluorophenyl) amino at the C 3 -position improved metabolic stability (Figures 7A,B)

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