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It is natural to speculate whether the inhibition of GS and GCL is an important evolutionary mechanism to keep GSH high, but not too high, in females during the childbearing years
Patients who remain on semaglutide or tirzepatide for years tend to maintain their weight loss, with some continuing to lose additional weight even after the first year
[17] [24] Regular eye monitoring is advised if pre-existing retinopathy is present
10.1097/GRF.0b013e3181db7d71 32
Less commonly reported effects include headaches , hair thinning , and changes in taste perception
Most of the current evidence comes from rodent models, whose pathophysiological processes differ from those of human DKD, and most of the existing studies focus on intervening in early lesions, and their pharmacological effects in reversing structural damage, such as glomerulosclerosis in advanced DKD, remains to be verified
