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When REDEFINE 4 results are published, they will provide the first and only direct comparison between these two treatments using the same population, the same endpoints, and the same measurement protocols
(2012) 130:S7782
Meanwhile, TB-500 is commonly used in research that explores cell movement and structural remodeling
The negative moderating effect of the total intervention period (weeks) suggests that indefinite extension of the intervention may lead to diminishing returns
For a given tumor type and combination regimen, a more practical path is to identify the most critical TME barriers and prioritize design objectives accordingly [60, 62]
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