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Additionally, patients should discuss with their provider if gastrointestinal side effects persist beyond the first few weeks at a stable dose or significantly impair quality of life, as dose modification may be appropriate

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Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized

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