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Long-term safety beyond 1-2 years is unknown because the trials havent run that long yet

For some people, it hits hard right after

Sabate M, Ibanez L, Perez E, Vidal X, Buti M, Xiiol X, Mas A, Guarner C, Forne M, Sola R, Castellote J, Rigau J, Laporte JR: Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a propective case series

Japanese Circulation Society

and 82201576 to Yun Z.), the Key Laboratory of Alzheimers Disease of Zhejiang Province (ZJAD-2021004 to Yun Z.) and STI2030-Major Projects (2022ZD0211800 to Yun Z.)