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It can also improve collagen fiber quality by increasing some structural skin elements (so-called proteoglycans), like decorin and lumican

GLP-1 weight loss uses medications that act on glucagon-like peptide-1 pathways, which are involved in appetite, fullness, digestion, and blood sugar regulation

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These approaches require further testing for more complex research questions such as assessment of meaningful treatment benefit or meaningful within-patient change for COAs