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Methods A comprehensive search was conducted across electronic databases (Ovid MEDLINE, Embase, PsycINFO, CINAHL, Cochrane) from inception to September 15, 2023

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Unlike obesity, which affects both sexes and typically presents with central fat accumulation, lipedema fat is more resistant to weight loss, diet, and bariatric surgery

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No human pharmacokinetic data exists to confirm whether these doses translate to effective systemic exposure