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GLP-1 has gained prominence not only for its receptor distribution across multiple systems, but also for its broad metabolic regulatory activities
Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushings disease before and after surgical cure
Notably, the insulinotropic and glucagonostatic effects are glucose dependent, and therefore the risk of hypoglycemia is very low during treatment with a GLP-1 RA
Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S
It is important to note that, in the other large type 2 diabetes cardiovascular outcome trials, there were no statistically significant associations with the use of GLP-1/GIP agonists and negative eye outcomes