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10.1146/annurev.bi.53.070184.003441 34 ForslundC.AspenbergP

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

For comparison, liraglutide 3.0 mg (the active comparator) produced 9.0% reduction

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