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J Neurosci 32:48124820 Dossat AM, Lilly N, Kay K, Williams DL (2011) Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake

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When directly injected into the brain, the mTOR antagonist, rapamycin, attenuates the antidepressant effects of ketamine [87]

For PDE1B, selectivity can be enhanced by targeting unique active-site residues, including His373 and Gln421