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doi: 10.1016/j.ecoenv.2021.112947 150 YuanATStillmanMJ
It's modified with an additional 13 amino acids at the N-terminus and a glutamic acid substitution, which significantly reduces its binding to IGF binding proteins
This GLP-1RA features the C-terminal extension of exendin-4, which was sequentially added to the human GLP-1 sequence that includes two substitutions (aminoisobutyric acid (Aib) at position 2 and glutamic acid (Glu) at position 16) (Extended Data Fig
doi:10.1007/BF02434082
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