If semaglutide (single agonist) is first generation, and tirzepatide and mazdutide (dual agonists) are second generation, then retatrutide (triple agonist) is the beginning of the third generation
It is not approved by the Food and Drug Administration (FDA) for use in humans
For instance, early oxidative stress may primarily induce mitochondrial damage and ferroptosis, subsequently triggering compensatory activation of mitophagy (Gross, 2024)
For example, since the 1940s, the field has been striving to develop an oral formulation of insulin, but still, no widely adopted oral formulation has been discovered
The vaginal ring releases hormones locally
Retatrutide (LY3437943) simultaneously activates GLP-1, GIP, and glucagon receptors, making it pharmacologically distinct from semaglutide or tirzepatide