This dual action remodels skin from within rather than simply adding new material on top of degraded structures
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Heterogeneity of release probability, facilitation, and depletion at central synapses
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The extent to which a once-weekly, continuously present amylin analogue reproduces these meal-linked effects as opposed to producing a tonic, non-pulsatile signal quite unlike physiological amylin is a genuinely open question, discussed further in our review of how cagrilintide affects gastric emptying and postprandial metabolism