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All parents and (where possible) children signed informed consent/assent forms

In post-marketing observations, there have been further reports of constipation with serious complications as well

28 (7-8):753-6 Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, and Atsushi Nakajima Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study BMC Gastroenterol

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Parkman HP, Jacobs MR, Mishra A et al

It is indicated for long-term use, but its safety and effectiveness over periods longer than two years have not been established