Of those who had used a GLP-1 agonist, just over 60% took it to treat a chronic condition like diabetes or heart disease, while 40% used it to lose weight
The red label pen shown delivers doses of 0.25 mg or 0.5 mg
Acta (BBA) - Gen
Oral administration of PF-06882961 shows evidence of glucose-lowering in healthy human study participants PF-06882961 was selected as a candidate for clinical studies based on its in vitro and in vivo pharmacologic and disposition profile, including potent agonism of the GLP-1R, preclinical disposition attributes (e.g., low metabolic CL int in human hepatocytes), good safety margins versus the hERG channel (IC 50 = 4.3 M, Table S4) and broad panel screening (Table S8), and selectivity versus related class B GPCRs (Table S9)
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Researchers using this concentration should strongly consider using a 0.3 mL insulin syringe (30 units max) for low doses, where each tick mark represents a smaller volume and allows finer control