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This system enables multistage precision delivery at the tissue, cellular, and even subcellular levels
However, large-scale randomized controlled trials in humans are absent, limiting evidence for clinical safety and efficacy claims
A clinical trial and a case-control study highlighted the effectiveness of GLP-1R agonists in reducing headache frequency and intracranial pressure in individuals with IIH, independent of weight loss [26, 27]
To remove excess salt, the eluted sample was desalted using a PD-10 desalting column packed with Sephadex G-25 resin (GE Healthcare) and eluted in 7 mL of 50 mM Tris-HCl, pH 8.0
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Our analysis of controlled studies with available results highlights the feasibility and benefits of various digital therapeutic and long-term care interventions (Supplementary Data 2), particularly in symptom relief and QoL improvements
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