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For Lilly internally, retatrutide moves from a hopeful pipeline asset to a pillar of the company's late-decade franchise alongside tirzepatide, which still dominates the dual-agonist segment, and oral orforglipron, which has its own ATTAIN-1 data showing 12.4% loss in non-diabetic adults

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Normally, almost all glutathione in the mitochondria is reduced glutathione, but in the presence of mitochondrial dysfunction, the proportion of oxidised glutathione increases due to the increased elimination of ROS

Some women may experience fewer than eight periods a year or have cycles longer than 35 days

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14%) [Figure 13.5]