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A vitamin B12 shot is an intramuscular injection of cobalamin given directly into a muscle, usually the upper arm or glute
doi: 10.3389/fgstr.2026.1790420 Received 18 January 2026 Revised 18 April 2026 Accepted 27 April 2026 Published 18 May 2026 Volume 5 - 2026 Edited by Glen A
Medication may be considered when clinically appropriate but its never the starting point
262 : E631E636
Comprehensive Medical Screening: Clinicians should evaluate for: Thyroid nodules or goiter : Baseline neck examination and review of recent thyroid ultrasound if clinically indicated Personal or family history of thyroid cancer : Particularly medullary thyroid carcinoma Comorbid conditions : Type 2 diabetes, cardiovascular disease, pancreatitis history Gastrointestinal disorders : Severe gastroparesis (potential contraindication) Renal function : Use caution in patients at risk for volume depletion/renal impairment Psychiatric conditions : Depression, eating disorders Pregnancy status : These medications are not recommended during pregnancy and should be discontinued when pregnancy is recognized Laboratory Assessment: Baseline testing should include: TSH and free T4 Comprehensive metabolic panel (renal and hepatic function) Lipid panel Hemoglobin A1c (if diabetic or prediabetic) Routine calcitonin screening or thyroid ultrasound is not recommended solely for GLP-1 therapy initiation
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