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In the EAE model, microbiota-induced elevation of L-Kyn significantly increases the infiltration of AhR-positive macrophages into the central nervous system, thereby alleviating neuroinflammation and demyelination (97)

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Notably, OsDHAR was found to be a monomer under both reducing and oxidizing (10 mM H 2 O 2 ) conditions (Supplemental Fig