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Semaglutide binds to GLP-1 receptors and stimulates insulin release from the pancreas
But for others - especially those in midlife or who believed their cycles were behind them - it can be deeply unsettling
Its like bringing a garden hose to a house fire
Patients should never discontinue GLP-1 therapy abruptly without medical consultation
Generally tolerated well
The PIONEER clinical trial programme, which evaluated oral semaglutide, showed that patients typically experienced decreased appetite as a common effect of treatment, with the MHRA/EMC SmPC listing decreased appetite as a common adverse reaction
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