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EMBO Rep 21:e49343
The enzyme NNMT normally changes nicotinamide, a form of vitamin B3, by using methyl groups, which lowers nicotinamide adenine dinucleotide (NAD+) levels
This process is partly mediated by the upregulation of brain-derived neurotrophic factor (BDNF), a neurotrophin that promotes neuronal survival, synaptic plasticity, and functional connectivity, ultimately supporting memory consolidation and executive function [77]
In the same region, MDD was associated with an upregulation of genes in the astrocytic branch (KYAT1, AADAT) and the glutamate transporter EAAT2 [66]
The vicious cycle of vitamin a deficiency: A review. Critical reviews in food science and nutrition vol
International Dairy Journal, 144 , Article 105691
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