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Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons

It is FDA-approved to treat both type 2 diabetes and, more recently, obesity

Weisiger, R

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The molecular design incorporates several structural features that are understood to enhance its pharmacological properties, based on published preclinical data and trial documentation: Fatty acid side chain attachment : Retatrutide is reported to be conjugated to a fatty acid chain via a linker, a modification that enables the molecule to bind to albumin (a protein in the bloodstream)

And this was cagrilintide alone, without any GLP-1 agonist combination