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Confirmatory secondary endpoints, including 6-minute walk distance and C-reactive protein levels, further supported semaglutides efficacy.(12,13) While not powered for mortality or HF hospitalization, exploratory analyses suggest benefits beyond weight loss alone.(4,12) An echocardiography substudy further explored semaglutides potential disease-modifying mechanisms in HFpEF pathophysiology in detail.(4) A comparison of key clinical trials with agents demonstrating benefit in HFpEF can be found in Table 1
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