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Patients who had taken Novos new CagriSema, a shot that combines semaglutide with an analog of another hormone, had slimmed down by 22.7 percent

Patients should contact their GP or diabetes team if they experience: Severe, persistent abdominal pain (potential pancreatitis) Persistent vomiting leading to dehydration Signs of hypoglycaemia (if taking alongside insulin or sulphonylureas) Severe or persistent constipation or abdominal distension Right upper quadrant pain, fever or jaundice (potential gallbladder problems) Sudden visual changes (especially in those with diabetic retinopathy) Allergic reactions or injection site problems Weight loss typically becomes noticeable within the first few weeks to months, though the rate varies considerably between individuals

Yes, nausea, vomiting, diarrheathese are not uncommon side effects

Here is the challenge with semaglutide

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Circana Mar 23 3 min read CHICAGO, March 23, 2026 The rise of GLP1 medication usage is emerging as a transformational force in the U.S