This interval, called perimenopause, is the adaptive reproductive phase, where there begin to be inconsistent oscillations in ovarian estrogen production as the follicles respond to gonadotrophin waves of follicle-stimulating hormone (FSH) [10]
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Bleeding lasting more than 7 days, soaking through more than one pad per hour for several hours, or causing iron deficiency anemia
Abdominal pain that hurts more over time
Diabetes Obes Metab 12 , 815824 (2010)