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Unlike branded drugs with fixed manufacturer pricing, compounded formulations allow licensed 503A pharmacies to vary cost based on supply chain efficiency and local regulatory compliance
The schedule above represents the minimum recommended time at each level, not a rigid requirement to increase every four weeks
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The DM control group consisted of patients with T2DM who were prescribed insulin or glucose-lowering drugs but not incretin-based drugs (GLP-1 RAs or DPP-4 inhibitors)
These incretin effects explain the initially surprising weight loss observed in the treatment groups of the cardiovascular trials, with subjects taking GLP-1/GIP agonists losing from 3% to 12% of their body weight
