GLP-1 receptor agonists carry known side effects including nausea, vomiting and constipation, plus rare but serious risks such as pancreatitis, thyroid concerns and gallbladder complications
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Preclinical data examines comparative receptor engagement versus dual agonists in adipose tissue models, hepatic lipid clearance pathways, and glucose-insulin axis signaling
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Recent trial data demonstrate that these benefits extend to individuals without diabetes, underscoring their role as cardiometabolic therapies rather than purely glucose-lowering medications [50, 51]
In contrast, in a six-week, randomized, single-blinded, placebo-controlled study in 60 MDD patients, supplemental curcumin (~880 mg/day of curcuminoids) alone yielded a similar response rate to the antidepressant, fluoxetine (a serotonin reuptake inhibitor [Prozac]