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Weeks 13-24: Optimization Phase This extended phase represents the sweet spot of the combined protocol

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Two open-label, single-sequence, crossover trials of healthy volunteers (trial 1: N = 52

One particularly instructive example comes from research using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced models of PD, where chronic administration of monoacylglycerol lipase inhibitors was found to not only preserve dopaminergic neurons in the substantia nigra but also induce a distinctive microglial activation profile characterized by increased release of neurotrophic factors and decreased expression of classical inflammatory markers [459]

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