Neonatal sevoflurane anesthesia downregulates DHHC5 expression, which leads to increased TfR1 endocytosis and dysregulated iron uptake, and ultimately triggers oligodendrocyte ferroptosis [95]
Effects of selenium and methylmercury upon glutathione and glutathione-S-transferase [PMID: 3985681] Laboratory literature summary: Effects of selenium and methylmercury upon glutathione and glutathione-S-transferase in mice
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though the first use of the ligand for a brain-targeting prodrug of methotrexate was reported in 1991 [22]
