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As the insulinotropic capacity of GLP-1 is partially retained in diabetic humans, GLP-1-based treatments have been successfully developed

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These medications are administered once or twice daily and are generally eliminated from the system within 12-24 hours after the last dose

Preclinical Pharmacology Comprehensive preclinical studies in diet-induced obese mice, diabetic mouse models, and non-human primates established the pharmacological proof of concept

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Further research must be conducted on the additional potential benefits of DPP-4 inhibitors before the recommendation for DPP-4 inhibitors over SGLT2 inhibitors or GLP-1 agonists as a second-line agent for patients with type 2 diabetes can be strengthened