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Notably, derivatives bearing L-sugar configurations outperformed their D-sugar counterparts, for instance, 3-O-(2,3,4-tri-O-acetyl--L-glucopyranosyl)-caudatin (Figure 1g) exhibited the highest activity against HepG2 cells (IC 50 3.11 M) (Li X

464 Systemic and pulmonary hypertension are the main clinical causes of heart enlargement, cardiac fibrosis, and eventually heart failure

Endocrinology 1998 139 2811-2817

Approved to manage blood sugar levels in adults with type 2 diabetes

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Developed as type 2 diabetes treatments, glucagon-like peptide-1 (GLP-1) receptor agonists mimic the effects of GLP-1, a hormone produced naturally by the body to regulate hunger and blood sugar