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Between 1 March and 19 August 2019, 706 participants were randomised in total , in a 6:1 ratio: approximately 506 to once-weekly subcutaneous cagrilintide at 0.3, 0.6, 1.2, 2.4 or 4.5 mg (100102 per dose group), 99 to once-daily liraglutide 3.0 mg, and 101 to volume-matched placebo