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4- Muscle Regeneration and Anti-Atrophy Protection Preclinical work 6 shows IGF-1 regulates matrix metalloproteinases (MMPs) and cytokines during tissue remodeling, ensuring balanced regeneration and reducing fibrotic scarring.IGF-1 also demonstrates protective effects against muscle atrophy by suppressing ubiquitin-proteasome pathways, helping preserve lean mass even during inactivity

After an extensive follow-up, the participants exhibited lower mortality versus the control group [28]

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Based on the higher, although non-significant, increase in mortality and neurological deficits, montelukast was utilized as an additional control for subsequent studies