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Lastly, we thank E
The only differences lie in FDA approval indication and marketing
Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]
No writing assistance was obtained in the preparation of this manuscript
Peptide therapy is not suitable for everyone and requires careful medical screening
Additionally, higher-dose semaglutide formulations (such as Wegovy 2.4 mg, licensed specifically for weight management) may be appropriate for certain patients meeting specific NICE criteria (TA875), though this requires specialist weight management services and is typically limited to a 2-year treatment duration
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