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Freeze-thaw cycling can disrupt the copper coordination sphere as well as degrade the peptide backbone

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patients receiving thyroid-hormone replacement or those with thyroid dysfunction should be monitored for changes in symptom control

The sequence of amino acids needs to be determined and is usually synthesized from the C-terminus to the N-terminus

The 3-month on, 2-month off structure preserves that sensitivity and allows natural GH secretion rhythms to reassert themselves during the rest phase

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