Research has explored its role in tissue repair signaling, including tendon and ligament healing and gut lining integrity
SGLT2 inhibitorrelated adverse effects, including genital mycotic infections, volume depletion, and rarely ketoacidosis, remain clinically relevant and should be considered when these agents are prescribed as part of combination therapy and importantly, the intrinsic risk of hypoglycemia with combined GLP-1 receptor agonist and SGLT2 inhibitor therapy is low because neither class directly stimulates insulin secretion in a glucose-independent manner and when hypoglycemia occurs, it is more commonly related to concomitant insulin or sulfonylurea use rather than the combination itself [41, 42, 44]
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Then participants switched to either receiving a combined injection of cagrilintide/semaglutide or continuing to get the separate injections for 8 weeks, for a total of 22 weeks of study medication