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The CAL treatment group in the tMCAO/R-induced CIRI rat models significantly reduced brain edema and BBB disruption, inhibited ACSL4, upregulated GPX4, and decreased Fe 2+ and MDA levels

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hepatic biological barriers also curtail the amount of medication that penetrates systemic circulation, thereby dampening therapeutic outcomes (Table 1) [20, 21]

In fact, Id argue it is not even good enough as a long-term maintenance dose

doi: 10.1902/ANNALS.1998.3.1.40 85 SalviG

In the majority of cases, the cardiometabolic advantages of GLP-1 receptor agonists outweigh concerns about minor heart rate elevations