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These diseases are mainly represented by the congenital defects of urea cycle, classical organic acidurias, and the defects of mitochondrial fatty acids oxidation, with hyperammonemia being more severe and frequent in the first two groups mentioned

Eur J Clin Pharmacol 1975;9:131-4

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The SARS-CoV-2 genome interacts with a few thousands of human metabolites in a specific manner to facilitate its infectious process 14,15,16