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GLP-1-based therapies and resmetirom operate through distinct and potentially complementary mechanisms: while resmetirom exerts direct hepatic effects by activating THR- to enhance mitochondrial function, reduce hepatic lipogenesis, and promote lipid oxidation specifically in hepatocytes, GLP-1 RAs and multi-agonists address the upstream metabolic drivers of MASLD including insulin resistance, obesity, and systemic inflammation
In the COPD-related immune microenvironment, ferroptosis mainly occurs in structural cells such as airway and alveolar epithelium, endothelium, and fibroblasts, and can also affect alveolar macrophages and neutrophils, impacting gas exchange and barrier integrity through structural damage, as well as promoting the maintenance of a chronic pro-inflammatory phenotype by altering cytokine profiles and macrophage polarization (109, 110)
Both agents affect glucose metabolism in opposing ways tesamorelin reduces insulin sensitivity whilst retatrutide enhances insulin secretion creating unpredictable glycaemic effects if combined
K.ZhangQ.ZhangF.HolstJ
This interview has been edited and condensed for clarity
Lifestyle changes Keeping a healthy weight through diet and exercise is key to polycystic ovary syndrome (PCOS) management
